Description

About Semax peptide (research compound)

Semax is a synthetic seven-amino-acid peptide derived from a fragment of adrenocorticotropic hormone (ACTH). Velora Research supplies Semax peptide as a 10mg lyophilized vial for in vitro and preclinical investigation by qualified laboratories and research professionals.

Every batch of Velora’s Semax peptide is independently verified by a third-party analytical laboratory using high-performance liquid chromatography (HPLC) for purity and mass spectrometry for identity. The batch-specific Certificate of Analysis is published on our COAs page and linked from this product page so researchers can confirm identity, purity, and molecular integrity before placing the compound into a study.

What is Semax peptide?

Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. The first four residues correspond to the ACTH (4-7) fragment, while the C-terminal Pro-Gly-Pro extension stabilizes the peptide against rapid enzymatic degradation. The molecular weight is approximately 813 g/mol. Semax was originally developed in the 1980s by the Institute of Molecular Genetics of the Russian Academy of Sciences and is sometimes referred to in literature simply as MEHFPGP.

In published preclinical and clinical research, Semax peptide has been characterized as a regulatory peptide acting through multiple signaling systems, with documented effects in cell-culture and animal models that include the BDNF (brain-derived neurotrophic factor) pathway, the dopaminergic system, and the melanocortin receptor family.

What is Semax peptide used for in research?

Researchers searching for what Semax peptide is used for are generally asking about the published research areas in which it has been characterized. Across peer-reviewed preclinical and clinical literature (primarily Russian and Eastern European groups), the principal research areas include:

• Neurotrophic-factor research. Cell-culture and animal-model studies of BDNF and NGF (nerve growth factor) expression after Semax peptide administration.
• Cerebrovascular research models. Animal-model studies of ischemia and post-ischemic recovery, where Semax peptide is one of the most extensively studied compounds in the Russian research literature.
• Cognitive research models. Animal-behavior assays studying attention, learning, and memory paradigms.
• Dopaminergic-system research. In-vitro and animal-model investigations of dopamine signaling pathways.
• Melanocortin receptor research. Receptor-binding studies characterizing Semax peptide interactions with MC4R and related receptors.

Velora Research supplies the Semax peptide solely as a research compound for further investigation of these and related research questions. All language above is research-frame and describes published preclinical literature. Nothing in this section constitutes a claim that Semax produces any specific outcome in humans, animals, or therapeutic applications.

Regulatory status: Russia vs. United States

Semax has a regulatory profile that is worth understanding before purchase. In Russia, Semax is approved as a clinical pharmaceutical under regional regulators for specific medical indications and is marketed under the Semax brand in a 0.1% intranasal formulation. In the United States, the European Union, and most other Western jurisdictions, Semax is not approved for any therapeutic use and is supplied solely as a research compound.

Velora Research’s Semax peptide product is a research-grade compound for in vitro and preclinical laboratory investigation. It is not the same product as the Russian Semax pharmaceutical, is not packaged or quality-controlled for human use, and is not for any therapeutic, nutritional, or cosmetic application.

Key specifications

Semax peptide pricing

Velora Research lists Semax peptide 10mg at a single transparent tier. The 10mg vial is sized to cover most pilot studies and multi-arm cell-culture experiments without re-ordering:

Free US shipping applies on orders over $200. Most orders process within 1 to 2 business days. International orders are accepted in accordance with applicable research regulations.

Buy Semax peptide from Velora Research: why qualified researchers choose us

Researchers screening Semax peptide suppliers typically evaluate vendors on five criteria. Velora was built around all five:

• Batch-level third-party COA. Every lot of Semax peptide is verified by an independent analytical lab using HPLC for purity and mass spectrometry for identity. The COA is downloadable from the product page and tied to the batch number printed on the vial.
• 99% or higher HPLC-verified purity. Identity, purity, and molecular integrity confirmed before any batch is released for sale.
• Documented production protocols. Lyophilized under controlled conditions, sealed in inert atmosphere, traceable from synthesis through shipment.
• US-based 2-day shipping. Free over $200; orders processed within 1 to 2 business days.
• Compliance-first sales policy. Sales restricted to qualified laboratories, institutions, and research professionals. Research-use-only terms acknowledged at checkout.

Reconstitution and storage guidance (research use)

Velora’s Semax peptide ships as a lyophilized powder. For in vitro studies, researchers typically reconstitute with bacteriostatic water (0.9% benzyl alcohol) or, for cell-culture protocols, with sterile water at a concentration matched to the assay. A common pilot ratio for the 10mg vial is 2 mL of bacteriostatic water, yielding a 5 mg/mL stock solution. Adjust per study design.

Published research protocols use two principal administration routes in animal-model studies: intranasal and subcutaneous. The intranasal route is used in much of the Russian Semax research literature, which also drives the high search interest in ‘semax nasal spray’ formulations. For Velora’s research-grade Semax peptide, any administration route in a research protocol should be selected and validated per the peer-reviewed literature and institutional approvals.

• Pre-reconstitution: store sealed at -20°C in a dry, dark environment. Avoid freeze-thaw cycles, which can degrade peptide integrity.
• Post-reconstitution: refrigerate at 2 to 8°C and use within the stability window established by the research protocol. Single-use aliquots reduce repeated exposure to room temperature.
• Handling: reconstitute and aliquot under sterile lab conditions with appropriate PPE.

Velora Research supplies bacteriostatic water as a separate product. Please refer to the peer-reviewed literature for protocol-specific reconstitution and handling parameters.

Semax peptide vs. Selank peptide: research-context comparison

Researchers evaluating Semax peptide for purchase often compare it to Selank, the other widely studied Russian-developed regulatory peptide. Summary of how the two differ at the mechanism level, drawn from published research:

Both peptides are supplied by Velora Research as research compounds for in vitro and preclinical investigation only. Researchers running comparative studies of the two compounds may consider purchasing both for direct head-to-head assay designs.